それなのにAnd yet, Despite this

"もっとも" and "それなのに" are both used to express contrast, however they have slightly different nuances. "もっとも" introduces a contrast by providing a condition or prerequisite that must be met before the main statement can be valid, somewhat similar to "provided that" or "although" in English. On the other hand, "それなのに" emphasizes the unexpectedness or surprising nature of a situation or outcome in light of previous information, much like "and yet" or "despite this" in English.

While both "それにしても" and "それなのに" imply contradictions to what was previously noted, they are used in somewhat differing contexts. 'それにしても' is often used to express a personal reaction when something exceeds expectations, acting as a transition to a new point or subject, roughly translating to "even so" or "nevertheless". On the other hand, 'それなのに' emphasizes contrast between an expected and actual outcome, which is similar to "despite this" or "and yet" in English.

"しかしながら" and "それなのに" both express contrast, but they are used slightly differently. "しかしながら" indicates a contradiction or difference between two facts, and is often used in more formal settings or written Japanese, setting the stage for the fact that will be revealed. On the other hand, "それなのに" emphasizes a sense of disappointment or surprise, expressing that something went against expectations despite certain circumstances or facts.

のに is used to express a contradiction between the expectation and the actual occurrence. It often conveys a sense of regret or disappointment regarding the outcome. On the other hand, それなのに is used when the contradiction is with previously stated information or known facts. It emphasizes the contrast between circumstances or expectations and actual situation, often with a sense of surprise or strong objection.

"それでも" and "それなのに" are similar as they both can be used to show contrast or contradiction. The main nuance difference is that "それでも" tends to be used when the speaker decides to do something or believes something despite the circumstances, so it's like saying "even so, despite that, I choose to…" On the other hand, "それなのに" is used to express disappointment or surprise when the expected result does not match the actual situation, like saying "despite this/that, it unfortunately turned out that…"

The main difference between ながらも and それなのに lies in the sense of conflict or contradiction they depict. ながらも expresses a contradiction or an unexpected result despite a certain condition or circumstance, such as "working hard yet being poor". On the other hand, それなのに is used to express disappointment or surprise that, despite what has been mentioned previously or is already known, the latter part of the sentence is not as expected, for instance admitting a mistake even though one knows the truth.

The main difference between these two phrases is the general connotation they convey. "くせに" (kuse ni) tends to have a negative or accusatory tone, often used when complaining or pointing out some sort of hypocrisy. On the other hand, "それなのに" (sore nanoni) has a more neutral tone, indicating a surprising or unexpected result that contradicts what was previously mentioned, but without the harsh judgement associated with "くせに".