Structure
Noun + なくして(は)
Verb + ことなくして(は)
Details
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Formal
About なくして(は)
なくしては is a hypothetical expression that indicates that 'if not for (A), then not (B)'. It may appear as either なしには, なしでは, or なくしては, with little variation in meaning. It is a combination of the conjunctive form of the い-Adjective ない, なく, the conjunction particle して, which highlights the word before it as a condition from which a determination can be made, and the adverbial particle は.
As the second part of なくしては sentences will also be negative, we can see the more literal meaning of 'from the lack of (A), a lack of (B) can be determined'. This 'determination' comes across quite strongly, and may be interpreted as '(B) is impossible without (A)'.
なくしては will appear after either nouns, or phrases that have been nominalized with こと.
As mentioned previously, なしには and なしでは may also be seen. These are just the noun 無し 'without', paired with either of the particle combinations には or では. なくしては is the most formal of the three.
The (B) part of なくしては sentences will almost always be some state of completion or desirable outcome that cannot be achieved without (A).
Examples
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スピーチ：「何よりまず我が友人トトロに感謝します。彼なくしては今日の私はなかったと言えるでしょう。」
Speech: 'First and foremost, I would like to thank my friend Totoro. It can be said that without him, I wouldn't be the person I am today.'
愛なくしては生きられないというが、それが苦痛になることもある。
They say that one cannot live without love, but sometimes it becomes a significant burden.
名言：「努力なくして成功なし。」
Wise saying: 'There is no success without hard work.'
トランジスタの開発なくして、現在の世界は成立しえない。
The world we know today is not possible without the development of transistors.
「ノーベル賞受賞はノーベル委員会に是認されることなくしては、ありえないことであろう。」
Receiving the Nobel prize is impossible without the approval of the Nobel Committee.
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